de Iongh Lab ~ Selected Publications
Publications
Lovicu FJ, McAvoy JW, de Iongh RU. (2011). Understanding the role of growth factors in embryonic development: insights from the lens. Phil Trans Royal Soc B. 366:1204-18. http://rstb.royalsocietypublishing.org/content/366/1568/1204.full.pdf+html
Martinez G, de Iongh RU. (2010). The lens epithelium in ocular health and disease. Int J Biochem Cell Biol. 42:1945-63. http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TCH-51491S2-2-B&_cdi=5171&_user=559483&_pii=S1357272510003316&_origin=search&_coverDate=12%2F31%2F2010&_sk=999579987&view=c&wchp=dGLbVzz-zSkWb&md5=808f5809b425d4c19b9f9f34ff995dd8&ie=/sdarticle.pdf
Zheng Z., de Iongh RU, Rathjen PD, Rathjen J. (2010). A requirement for FGF signalling in the formation of primitive streak-like intermediates from primitive ectoderm in culture. PLoS One 5, e12555. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012555
Martinez G, Wijesinghe M, Turner K., Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU. (2009) Conditional mutations of β-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest, Ophthalmol, Vis Sci, 50:4794-4806. http://www.iovs.org/cgi/content/full/50/10/4794
Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU. (2008). Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev Biol. 2008 321:420-33. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDG-4SY6W7J-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=12f3f72d7fed0b4767f0ea41f9a3e5b4
Kwek J, De Iongh R, Nicholas K, Familari M. (2008). Molecular insights into evolution of the vertebrate gut: focus on stomach and parietal cells in the marsupial, Macropus eugenii. J Exp Zoolog B Mol Dev Evol. 312:613-24. http://www3.interscience.wiley.com/journal/119883023/abstract
O'Connor MD, Wederell ED, de Iongh R, Lovicu FJ, McAvoy JW. (2008). Generation of transparency and cellular organization in lens explants. Exp Eye Res. 86:734-45. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WFD-4RRNXS9-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=10&md5=3a05f1ad5d3dcf5245419eb18451cdb9
Wederell ED, de Iongh RU. (2006). Extracellular matrix and integrin signaling in lens development and cataract. Semin Cell Dev Biol. 17:759-76. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WX0-4M6RXKR-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=c557914d94ba3f9f30d7fa1efe9387d8
Kokkinos MI; Brown, HJ; de Iongh RU. (2007). Focal adhesion kinase expression and activation during lens development. Mol Vis, 13:418-30. http://www.molvis.org/molvis/pdf.cgi?Kokkinos,13,45
Zariwala MA, Leigh MW, Ceppa F, Kennedy MP, NooneP G,.Carson JL, Hazucha MJ, Lori1 A, Horvath J, Olbrich H, Loges NT, Bridoux A-M, Pennarun G, DuriezB, EscudierE, Mitchison HM, Chodhari R, Chung EMK, Morgan LM, de Iongh RU, Rutland J, Pradal U, Omran H, Amselem S,. Knowles MR. (2006). Mutations of DNAI1 in Primary Ciliary Dyskinesia: Evidence of founder effect in a common mutation. Am J Respir Crit Care Med, 174(8):858-66
de Iongh RU, Abud HE, Hime GR. (2006). Wnt/Frizzled signaling in eye development and disease. Front Biosci 11:2442-64.
de Iongh RU, Wederell E, Lovicu FJ, McAvoy JW. (2005). TGFb-induced EMT in the lens: a model for cataract formation. Cells Tissues & Organs 179(1-2):43-55.
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=224197&ContentOnly=false
Wederell ED, Brown H, McAvoy JW, Chamberlain CG, de Iongh RU. (2004). Laminin-binding integrins in rat lens morphogenesis and their regulation during fibre differentiation. Exp Eye Res, 81(3):326-39. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WFD-4FRB7T3-3&_user=559483&_coverDate=09%2F30%2F2005&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000028178&_version=1&_urlVersion=0&_userid=559483&md5=2bbef625e6c41c51d4ebddadbcd0f35c
de Iongh RU, Chen Y, Kokkinos MI, McAvoy JW. (2004). BMP and activin receptor expression in lens development.Mol Vis; 10:566-76. http://www.molvis.org/molvis/v10/a69/
Stump RJW, Ang S, Chen Y, von Bahr T, Lovicu FJ, Pinson K, de Iongh RU, Yamaguchi TP, Sassoon DA, McAvoy JW. (2003). A role for Wnt/[ß]-catenin signaling in lens epithelial differentiation. Dev Biol. 259:48–61.http://www.sciencedirect.com/science/journal/00121606
de Iongh, R. U., Lovicu, F. J, Overbeek, P. A., Schneider, M. D., Joya, J., Hardeman, E. and McAvoy, J. W. Requirement for TGFb receptor signaling during terminal lens fibre differentiation. Development, 2001;128:3995-4010. http://dev.biologists.org/cgi/content/abstract/128/20/3995
de Iongh RU, Gordon-Thomson C, Hales AM, Chamberlain CG, McAvoy JW. TGFb receptor expression in the lens: implications for differentiation and cataractogenesis. Exp Eye Res, 2001;72:649-659.http://www.elsevier.com/wps/find/journaldescription.cws_home/622827/description#description
McAvoy JW, Chamberlain CG, de Iongh RU, Hales AM, Lovicu FJ. (2000). Peter Bishop Lecture: growth factors in lens development and cataract: key roles for FGF and TGFb. Clin Exp Ophthalmol, 28:133-139. http://www.blackwellpublishing.com/journal.asp?ref=1442-6404
McAvoy JW, Chamberlain CG, de Iongh RU, Hales AM, Lovicu FJ. (1999). Lens development, Eye, 13:425-437. http://www.nature.com/eye/
Gordon -Thomson C, de Iongh RU, Hales AM, Chamberlain CG, McAvoy JW. (1998). Differential cataractogenic potency of TGFb1, TGFb2 and TGFb3 and their expression in the postnatal rat eye. Invest Ophthalmol Vis Sci, 39:1399-1409. http://www.iovs.org/
de Iongh RU, Lovicu FJ, Chamberlain CG, McAvoy JW. Differential expression of FGF receptors during rat lens morphogenesis and growth. Invest Ophthalmol Vis Sci, 1997;38:1688-1699. http://www.iovs.org/
Lovicu FJ, de Iongh RU, McAvoy JW, (1997). Expression of FGF-1 and FGF-2 mRNA during lens morphogenesis, differentiation and growth. Curr Eye Res, 16:222-230. http://www.tandf.co.uk/journals/titles/02713683.asp
de Iongh RU, Lovicu FJ, Hanneken A, Baird A, McAvoy JW. (1996). FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth. Dev Dynam, 206:412-426. http://www3.interscience.wiley.com/cgi-bin/jhome/38417
Schulz MW, Chamberlain CG, de Iongh RU, McAvoy JW. (1993). Acidic and basic FGF in ocular media and lens: implications for lens polarity and growth patterns. Development, 118:117-126. http://dev.biologists.org/cgi/content/abstract/118/1/117
de Iongh RU, McAvoy JW. (1993). Cellular localisation of aFGF during early lens development by a triple fluorescent labelling technique. J Comput Assist Microsc, 5:31-36. http://www.kluweronline.com/issn/1040-7286/contents
de Iongh R, McAvoy JW. Distribution of acidic and basic fibroblast growth factors (FGF) in the foetal rat eye: implications for lens development. Growth Factor, 1992;6:159-177. http://www.tandf.co.uk/journals/titles/08977194.asp
McAvoy JW, Chamberlain CG, de Iongh RU, Richardson NA, Lovicu FJ. (1991). The role of fibroblast growth factor in eye lens development. Ann NY Acad Sci, 638:256-274.http://www.annalsnyas.org/
Other Publications
Sharp J, Lefevre C, Kwek J, Topcic D, Buscara L, Pooley C, de Iongh RU, Familari M, Nicholas K. (2010). Marsupial milk - identifying signals for regulating mammary function and development of the young. In: Marsupial Genetics and Genomics. Eds: P. D. Waters J. E. Deakin and J. A. Marshall Graves, pp. 317-337. London: Springer.
Rutland J, Morgan L, de Iongh RU, (2008). Respiratory Ciliary Dysfunction. In: Pediatric Respiratory Medicine. 2nd Edn. Eds: Taussig LM, Landau LI; pp. 979-987. Elsevier. New York. ISBN-13: 978-0-323-04048-8. publication date: APR-2008.
Rutland J, Morgan L, de Iongh RU, (2004). Modulation of Ciliary Function by Drugs and Other Agents. In: Therapy for Mucus Clearance Disorders. Eds: BK Rubin and K. van der Schans, pp. 225-306. Marcel Dekker. Inc. New York.
Rutland J, de Iongh RU, (1999). Ciliary Dysfunction. In: Pediatric Respiratory Medicine. Eds: Taussig LM, Landau LI, Mosby-Year Book. New York. ISBN: 0801674069.
Rutland J, Morgan L, Waters KA, van Asperen P, de Iongh RU, (1998). Diagnosis of Primary Ciliary Dyskinesia. In: Cilia, Mucus, and Mucociliary Interactions. Eds: G. Baum, Priel Z, Roth Y, Liron N, Ostfeld EJ. pp. 407-428. Marcel Dekker, New York. ISBN: 0824701380.
Rutland J, Morgan L, de Iongh RU. (1999). A twist in the tale: primary ciliary dyskinesia explained. Modern Medicine, June 1999, 37-43.