Murray Lab ~Neurotrophin Signaling laboratory
Principal investigator: Dr. Simon Murray
The research focus of the Neurotrophin Signaling Laboratory centers on a family of growth factors essential for normal nervous system function known as the neurotrophins. The laboratory is interested in the structure, biochemistry, and mechanisms of neurotrophin signaling, as well as several aspects of their biology, in particular the role they play in the myelinating process. In this regard, we are particularly interested in the impact that Brain Derived Neurotrophic Factor (BDNF) has upon the interactions between neurons and glial cells that regulate development of both central and peripheral myelin.
The lab utilizes in vitro, in vivo and genetic techniques to dissect out the roles that the neurotrophins play in regulating central and peripheral nervous system myelination. Our research has extended into identifying the molecular signals the neurotrophins activate to promote Central Nervous System myelination. This has relevance to neurological conditions that result in demyelinating diseases and neuropathies, as interrogation of the signaling pathways that promote myelination will be of distinct potential therapeutic benefit. The laboratory maintains close collaborative interactions with the Multiple Sclerosis research Division at the Florey Neuroscience Institutes. We are located in the Centre for Neuroscience, on the 7th floor (West Wing) of the Medical Building.