Young Lab ~ Selected Publications
2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998
2010
HOTTA, R., ANDERSON, R.B., KOBAYASHI, K., HEWGREEN, D.F. and YOUNG, H.M. (2009) Effects of age, presence of neurons and lack of endothelin-3 on the ability of enteric neural crest-derived cells to colonize explants of recipient gut. Neurogastro Motil 22:331-e86.
HAO, M.M., MOORE, R.E., ROBERTS, R.R., NGUYEN, T., FURNESS, J.B. ANDERSON, R.B., and YOUNG, H.M. (2010). The role of neural activity in the migration and differentiation of enteric neuron precursors. Neurogastro Motil 22(5):e127-37.
YOUNG, H.M., CANE, K.N. and ANDERSON, C.R. (2010) Development of the autonomic nervous system: A comparative view. Autonom Neurosci (in press).
ROBERTS, R.R., ELLIS, M., GWYNNE, R.M., BERGNER, A.J., LEWIS, M., BECKETT, E.A., BORNSTEIN, J.C. and YOUNG, H.M. (2010). The first intestinal motility patterns in fetal mice are not mediated by neurons or interstitial cells of Cajal. J Physiol 588:1153-69.
2009
BURNS, A.J., ROBERTS, R.R., BORNSTEIN, J.C. and YOUNG, H.M. (2009). Development of the enteric nervous system and its role in intestinal motility during fetal and early post-natal stages. Semin. Pediatr. Surg. 18:196-205.
HAO, M., ANDERSON, R.B., KOBAYASHI, K., WHITINGTON, P.M. and YOUNG, H.M. (2009). The migratory behaviour of immature enteric neurons. Dev. Neurobiol. 69:22-35.
HAO, M. and YOUNG, H.M. (2009) Development of enteric neuron diversity. J. Cell. Mol. Med. 13:1193-1210
HOTTA, R., PEPDJONOVIC, L., ANDERSON, R.B., ZHANG, D., BERGNER, A.J., LEUNG, J., PEBAY, A., YOUNG, H.M., NEWGREEN, D.F. and DOTTORI, M. (2009) Small molecule induction of neural crest-like stem cells from human embryonic stem cell-derived progenitor cells. Stem Cells 27:2896-2905
HOTTA, R., NATARAJAN, D. and THAPAR, N. (2009) Potential of cell therapy to treat pediatric motility disorders. Semin. Pediatr. Surg. 18:263-73.
YOUNG, H.M., ANDERSON R.B. and NEWGREEN, D.F. (2009) Neural Crest. In: Squire L.R. (ed.) “The New Encyclopedia of Neuroscience”, volume 6, pp 123-133. Academic Press, Oxford. This article also appears in Lemke, G. (ed.) “Developmental Neurobiology”, Academic Press.
2008
STEWART, A.L., ANDERSON, R.B., KOBAYASHI, K. and YOUNG, H.M. (2008). Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice. BMC Dev. Biol. 8:73.
CALLAHAN, T., YOUNG, H.M., ANDERSON, R.B., ENOMOTO, H. and ANDERSON, C.R. (2008) Development of satellite glia in mouse sympathetic ganglia: GDNF and GFRa1 are not essential. Glia (in press, accepted 20 April, 2008).
ABUD, H.A., YOUNG, H.M. and Newgreen, D.F. (2008) Analysing tissue and gene function in intestinal organ culture. In “Wnt Signaling: Methods and Model Systems”, edited by E. Vincan, Humana Press (in press).
ROBERTS, R.R., BORNSTEIN, J.C., BERGNER, A.J. and YOUNG, H.M. (2008). Disturbances of colonic motility in mouse models of Hirshsprung’s disease. Am. J. Physiol. 294:G996-G1008 .
YOUNG, H.M. (2008). Functional development of the enteric nervous system – from migration to motility. Neurogastro Motil 20 Suppl 1:20-31.
YOUNG, H.M. (2008). On the outside looking in – longitudinal muscle development in the gut. Neurogastro. Motil 20:431-433.
top of page2007
FLYNN, B, Bergner, A.J., Turner, K.N., Young, H.M. and ANDERSON, R.B. (2007) Effect of Gdnf haploinsufficiency on rate of migration and number of enteric neural crest-derived cells. Dev. Dyn. 236:134-141.
STEWART, A.L., YOUNG, H.M., POPOFF, M. and ANDERSON, R.B. (2007). Effects of pharmacological inhibition of small GTPases on enteric neural crest cell migration and axon extension. Dev. Biol. 307:92-104.
ANDERSON, R.B., BERGNER, A.J., TANIGUCHI, M., FUJISAWA, H., FORRAI, A., ROBB, L. and YOUNG, H.M. (2007). Effects of different regions of the embryonic gut on the migration of enteric neural crest-derived cells: A role for Sema3A, but not Sema3F. Dev. Biol. 305:287-299.
ROBERTS, R.R., MURPHY, J.F., YOUNG, H.M. and BORNSTEIN, J.C. (2007). Development of colonic motility in the neonatal mouse – studies using spatiotemporal maps. Am J Physiol 292:G930-G938.
2006
ANDERSON, R.B., STEWART, A.L. and YOUNG, H.M. (2006). The phenotypes of neural crest-derived cells in vagal and sacral pathways. Cell Tissue Res. 323:11-25.
ANDERSON, R.B., NEWGREEN, D.F. and YOUNG, H.M. (2006). Neural crest and the development of the enteric nervous system. Adv Exp Med Biol. 589:181-96.
ANDERSON, R.B., TURNER, K.N., NIKONENKO, A.G., HEMPERLY, J., SCHACHNER, m. and YOUNG, H.M. (2006). The cell adhesion molecule L1 is required for chain migration of neural crest cells in the developing mouse gut. Gastroenterology 130:1221-32.
YOUNG, H.M., NEWGREEN, D.F. and BURNS, A.J. (2006) Development of the enteric nervous system in relation to Hirschsprung’s disease. Chapter in: "Embryos, genes and birth defects", Ed: Ferretti P, Copp A, Tickle C, Moore G, John Wiley and Sons Ltd, Chichester, England, pp 263-300.
2005
YOUNG, H.M., TURNER, K.N. and BERGER, A.J. (2005). The location and phenotype of proliferating neural crest-derived cells in the developing mouse gut. Cell Tissue Res. 320:1-9.
YOUNG, H.M. (2005). Neural stem cell therapy and GI biology. Gastroenterology 129:2092-2095.
2004
ANDERSON, R.B., ENOMOTO, H.,BORNSTEIN, J.C. and YOUNG, H.M. (2004) The enteric nervous system is not essential for the propulsion of gut contents in fetal mice.Gut. 10 :1546-7.
YAN, H., BERGNER, A.J., ENOMOTO, H., MILBRANDT, J., NEWGREEN, D.F. and YOUNG, H.M. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent.Dev. Biol. 272 (1):118-33.
YOUNG, H.M., ANDERSON, R.B., and ANDERSON, C.R. (2004) Guidance cues involved in the development of the peripheral autonomic nervous system.Auton. Neurosci. 112 (1-2):1-14.
YOUNG, H.M., BERGNER, A.J., ANDERSON, R.B., ENOMOTO, H., MILBRANDT, J., NEWGREEN, D.F. and WHITINGTON, P.M. (2004) Dynamics of neural crest-derived cell migration in the embryonic mouse gut.Dev. Biol. 270 (2):455-73.
BURNS, A.J., PASRICHA, P.J. and YOUNG, H.M. (2004) Enteric neural crest-derived cells and neural stem cells: biology and therapeutic potential. Neurogastroenterol. Motil. 1 :3-7.
2003
YOUNG, H.M., BERGNER, A.J. and MÜLLER, T. (2003) Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine.J. Comp. Neurol. 456 :1-11.
YAN, H., NEWGREEN, D. and YOUNG, H.M. (2003) Developmental changes in neurite outgrowth responses of dorsal root and sympathetic ganglia to GDNF, Neurturin, and Artemin. Dev. Dynam. 227 (3):395-401.
STEWART, A. L., ANDERSON, R. B. and YOUNG, H. M. (2003) Characterization of lacZ-expressing cells in the gut of embryonic and adult DbetaH-nlacZ mice.J Comp Neurol. 464 :208-219.
2002
ALLEN, J., CANTY, A.J., SCHULZ, S., HUMPHREY, P.P.A., EMSON, P.C., and YOUNG, H.M. (2002) Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice.J. Comp. Neurol. 454 (3):329-40.
NEWGREEN, D. and YOUNG, H.M. (2002). The enteric nervous system: Development and developmental disorders - Part 1.Pediatr. Dev. Pathol. 5 :224-247.
NEWGREEN, D. and YOUNG, H.M. (2002). The enteric nervous system: Development and developmental disorders - Part 2.Pediatr. Dev. Pathol. 5 :329-349.
YOUNG, H.M., JONES, B.R. and McKEOWN, S.J. (2002) The projections of early enteric neurons are influenced by the direction of neural crest cell migration.J. Neurosci. 22 :6005-6018.
2001
McKEOWN, S.J., CHOW, C.W. and YOUNG, H.M. (2001). The development of the submucous plexus in the large intestine of the mouse. Cell Tissue Res. 303 :301-305.
PORTBURY, A.L., GRKOVIC, I., YOUNG, H.M. and FURNESS, J.B. (2001) Relationship between post-synaptic NK1 receptor distribution and nerve terminals innervating myenteric neurons in the guinea-pig ileum.Anat. Rec. 263 :248-254.
YOUNG, H.M., HEARN, C.J., FARLIE, P.G., CANTY, A.J., THOMAS P.Q. and NEWGREEN, D.F. (2001) GDNF is a chemoattractant for enteric neural cells.Dev. Biol. 229 :503-516.
YOUNG H.M. and NEWGREEN D.F. (2001). Enteric neural crest-derived cells: Origin, identification, migration and differentiation.Anat. Rec. 262 :1-15.
2000
YOUNG, H.M. (2000). Increased expression of p75 NTR by neural crest-derived cells in vivo during mitosis.Neuroreport 11 :725-728.
YOUNG, H.M., HEARN, C.J. and NEWGREEN, D.F. (2000). Embryology and development of the enteric nervous system. Gut 47 (Suppl 4):IV12-IV14.
YOUNG, H.M., ANDERSON, C.R. and FURNESS, J.B. (2000). Nitric oxide in the peripheral autonomic nervous system. In: Handbook of Chemical Neuroanatomy, Volume 16, "Functional Neuroanatomy of the Nitric Oxide System", Eds: H.W.M. Steinbusch, J. de Vente and S. Vincent, Elsevier Science B.V., Amsterdam, pp. 215-265.
1999
HEARN, C.J., YOUNG, H.M., CIAMPOLI, D., LOMAX, A.E.G. and NEWGREEN, D. (1999). Catenary cultures of embryonic gastrointestinal tract support organ morphogenesis, motility, neural crest cell migration and cell differentiation.Dev. Dyn. 214 :239-247.
SANG, Q., CIAMPOLI, D., GREFERATH, U., SOMMER, L. and YOUNG, H.M. (1999). The innervation of the esophagus of mice that lack MASH1.J. Comp. Neurol. 408 :1-10.
WAY, K.J., YOUNG, H.M. and REID, J.J. (1999). The effect of diabetes on the activity and localisation of nitric oxide synthase in the rat anococcygeus muscle.J. Autonom. Nerv. Sys. 76 :35-44.
YOUNG, H.M., CIAMPOLI, D., HSUAN, J. and CANTY, A.J. (1999). Expression of Ret-, p75NTR-, Phox2a-, Phox2b- and tyrosine hydroxylase immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut.Dev. Dyn. 216 :137-152.
YOUNG, H.M. (1999). The embryological origin of the interstitial cells of Cajal.Microscopy Research and Technique 47 :303-308.
1998
SANG, Q. and YOUNG, H.M. (1998). The identification and chemical coding of cholinergic neurons in the small and large intestine of the mouse.Anat. Rec. 251 :185-199.
SANG, Q. and YOUNG, H.M. (1998). The origin and development of the vagal and spinal innervation of the external muscle of the mouse esophagus.Brain Res. 809 :253-268.
YOUNG, H.M. and CIAMPOLI, D. (1998). Transient expression of neuronal nitric oxide synthase in neurons of the submucous plexus of the mouse small intestine.Cell Tissue Res. 291 :395-401.
YOUNG, H.M., HEARN, C.J., CIAMPOLI, D., SOUTHWELL, B.R., BRUNET, J.-F. and NEWGREEN, D.F. (1998). A single rostro-caudal colonisation of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret and p75, and by explants grown under the kidney capsule or in organ culture.Dev. Biol. 202 :67-84.
YOUNG, H.M., TORIHASHI, S., CIAMPOLI, D. and SANDERS, K.M. (1998). Identification of neurons that express stem cell factor in the small intestine of the mouse.Gastroenterology 115 :898-908.